Protein Carbamylation in Kidney Disease

Kalim et al AJKD Fig 1

A recent In Translation article by Kalim et al in AJKD reviews the clinical relevance of protein cabamylation in kidney disease. Carbamylation refers to the post-translational modification of proteins (other examples being phosphorylation and glycation) that occurs when adding a carbamoyl moiety (-CONH2) to amino acids. It is induced by exposure to urea and its […]

Test Your Knowledge: Anion Gap in Metabolic Acidosis

eAJKD

The serum anion gap is a common tool used in clinical practice. Recent advances have led to a new mnemonic GOLD MARK to differentiate the various causes of anion gap metabolic acidosis. A recent article in AJKD by Vichot and Rastegar discusses the use of anion gap in metabolic acidosis. The following questions will test […]

The Name Game: An Improved Search Algorithm for Finding CKD Literature

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What is in a name? The field of nephrology has grown accustomed to name changes. It seems we are never satisfied with only one name. Is it the Renal Division or the Division of Nephrology? How about Renal Week, or what we now call Kidney Week? What used to be acute renal failure is now […]

Does CKD Result in Increased Unnecessary Hospitalization?

eAJKD

Invited commentary from Dr. Swapnil Hiremath Chronic Kidney Disease (CKD) has been recognized as a risk factor for increased morbidity and mortality ever since the seminal report from Go et al using the Kaiser Permanente data. It is thus fitting that Wiebe et al, on behalf of the Alberta Kidney Disease Network, now report in […]

Residual Renal Function and RAAS Blockade in Hemodialysis Patients: What Is the Benefit?

Krista Dybtved Kjærgaard

There is strong evidence that residual renal function (RRF) remains important even after the start of dialysis. Regardless of dialysis modality, RRF has been associated with increased survival. Randomized clinical trials in peritoneal dialysis (PD) demonstrate preservation of RRF in patients treated with renin-angiotensin-aldosterone system (RAAS) blockade, but such data in hemodialysis (HD) patients are […]

PD in Patients with Gastrostomy Tubes (& vice versa): Challenging but Doable

eAJKD

Literature on the feasibility of gastrostomy tubes in peritoneal dialysis (PD) patients is still sparse. Paudel and Fan’s recent article in AJKD should give nephrologists some confidence when dealing with this situation. The article describes two cases: a 68-year-old man on continuous ambulatory PD (CAPD) for ESRD from IgA nephropathy. He required percutaneous endoscopic gastrostomy […]

Effect of eGFR on Vitamin D Metabolism: A Participant-Level Data Analysis of 5 Cohort Studies

de Boer et al AJKD fig 4

Invited commentary from Dr. Sairah Sharif It is appreciated that CKD leads to reduced production of active 1,25-dihydroxyvitamin D3 (1,25(OH)D3). However the effects of estimated glomerular filtration rate (eGFR) on vitamin D catabolism are not well known. In earlier studies it has been shown that CKD is characterized by reduced vitamin D catabolism. A recent […]

Recap of eAJKD’s coverage of the 2014 World Transplant Congress

eAJKD

Check out all of the coverage of this year’s World Transplant Congress by eAJKD’s Dr. Vinay Nair on Twitter (@eAJKD) and below: Detection of C3d binding donor specific antibodies at diagnosis of humoral rejection predicts renal graft loss Inducible Knockdown of SHROOM3 Reduces Renal Fibrosis in Mice: From Bedside to Bench Late Breaking Oral Session: […]

#WTC2014: One Center’s Discard Is Another Center’s Transplant

eAJKD

Dr. Kent from Mt. Sinai, NY, presented interesting data about outcomes of kidney sharing in the NY organ donor network.  Patients listed for kidney transplantation in NY have among the highest wait times in the USA. Clearly there are not enough local organs for the numerous patients waiting for transplantation in NY.  Because of this […]

#WTC2014: New weapons in the fight against antibodies? Maybe… (part 2)

eAJKD

2. C1 inhibitor (C1INH) If you remember your allergy immunology rotation you may remember that this drug is approved for hereditary angioedema. It works proximally in the complement cascade and blocks the classic and MBL pathway of complement activation. With all of the interest eculizumab received in kidney transplantation its no suprise that studies are […]

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