Pregnancy in IgA Nephropathy: A Blessing or Curse?


Kidney disease was historically considered a contraindication to pregnancy, and termination of pregnancy was often recommended. However, the data on successful outcomes in pregnant women with CKD are increasing. The first successful pregnancy in a dialysis patient was reported in 1971. In a recent study published in AJKD, Liu et al analyzed the impact of pregnancy […]

ORCID: What Physicians Need To Know…

Dr Matt Sparks ORCID profile

Have you ever tried to look up a colleague’s publication on PubMed, and found hundreds of J Smith’s? Or have you been cited in different forms by different publications?  Researchers, universities, and publishers have long sought a better way to identify and differentiate authors. Enter ORCID (Open Researcher and Contributor ID). What is ORCID? ORCID […]

Before and After TREAT


In a recent article published in AJKD, Thamer at al did a retrospective observational investigation of the ESA prescribing patters before and after publication of the TREAT trial, and even referred to TREAT as a “watershed” study. As erythropoietin rose to popularity, there was general agreement that blood transfusions are not indicated for Hgb > […]

Test Your Knowledge: Interstitial Nephritis

Interstitial Nephritis TYK - Question 1

In a recent article published in AJKD, Muriithi et al report a large series of 133 patients who had biopsy-proven acute interstitial nephritis at a single center. The following questions will test your pathology knowledge on this topic. Post prepared by and all images courtesy of Tibor Nadasdy, MD, eAJKD Contributor and AJKD Kidney Biopsy […]

Protein Carbamylation in Kidney Disease

Kalim et al AJKD Fig 1

A recent In Translation article by Kalim et al in AJKD reviews the clinical relevance of protein cabamylation in kidney disease. Carbamylation refers to the post-translational modification of proteins (other examples being phosphorylation and glycation) that occurs when adding a carbamoyl moiety (-CONH2) to amino acids. It is induced by exposure to urea and its […]

Test Your Knowledge: Anion Gap in Metabolic Acidosis


The serum anion gap is a common tool used in clinical practice. Recent advances have led to a new mnemonic GOLD MARK to differentiate the various causes of anion gap metabolic acidosis. A recent article in AJKD by Vichot and Rastegar discusses the use of anion gap in metabolic acidosis. The following questions will test […]

The Name Game: An Improved Search Algorithm for Finding CKD Literature


What is in a name? The field of nephrology has grown accustomed to name changes. It seems we are never satisfied with only one name. Is it the Renal Division or the Division of Nephrology? How about Renal Week, or what we now call Kidney Week? What used to be acute renal failure is now […]

Does CKD Result in Increased Unnecessary Hospitalization?


Invited commentary from Dr. Swapnil Hiremath Chronic Kidney Disease (CKD) has been recognized as a risk factor for increased morbidity and mortality ever since the seminal report from Go et al using the Kaiser Permanente data. It is thus fitting that Wiebe et al, on behalf of the Alberta Kidney Disease Network, now report in […]

Residual Renal Function and RAAS Blockade in Hemodialysis Patients: What Is the Benefit?

Krista Dybtved Kjærgaard

There is strong evidence that residual renal function (RRF) remains important even after the start of dialysis. Regardless of dialysis modality, RRF has been associated with increased survival. Randomized clinical trials in peritoneal dialysis (PD) demonstrate preservation of RRF in patients treated with renin-angiotensin-aldosterone system (RAAS) blockade, but such data in hemodialysis (HD) patients are […]

PD in Patients with Gastrostomy Tubes (& vice versa): Challenging but Doable


Literature on the feasibility of gastrostomy tubes in peritoneal dialysis (PD) patients is still sparse. Paudel and Fan’s recent article in AJKD should give nephrologists some confidence when dealing with this situation. The article describes two cases: a 68-year-old man on continuous ambulatory PD (CAPD) for ESRD from IgA nephropathy. He required percutaneous endoscopic gastrostomy […]


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