A recent Core Curriculum in AJKD from Theresa K. Chen and colleagues focuses on one of the most bread-and-butter topics for nephrology—reducing kidney function decline in patients with chronic kidney disease (CKD).  This paper provides a comprehensive review of various clinical trials as they apply to everyday clinical nephrology practice. It focuses on various opportunities that allow for slowing  the progression of CKD. A graphical abstract and summary of tables for the paper are outlined in this piece.

Blood Pressure control:

Table 1 from Chen et al, AJKD © National Kidney Foundation

RAAS inhibition:

Table 3 from Chen et al, AJKD © National Kidney Foundation

Glycemic control:

Table 4 from Chen et al, AJKD © National Kidney Foundation

SGLT2 inhibitors and GLP1-receptor agonists:

Figure 2 from Chen et al, AJKD © National Kidney Foundation

Chronic metabolic acidosis and dietary protein restriction:

Figure 3 from Chen et al, AJKD © National Kidney Foundation

— Post prepared by Trisha K. Patel @TrishaKPatelDO and Yara Shams (AJKDBlog Guest Contributors) and Edgar V. Lerma @edgarvlermamd, AJKD Social Media Advisory Board member.

To view Chen et al, please visit AJKD.org.

Title: Reducing Kidney Function Decline in Patients With CKD: Core Curriculum 2021
Authors: Teresa K. Chen, Christopher J. Sperati, Sumeska Thavarajah, and Morgan E. Grams
DOI: 10.1053/j.ajkd.2020.12.022

Articles in the Core Curriculum aim to give trainees in nephrology a strong knowledge base in core topics in the specialty by providing an overview of the topic and citing key references, including the foundational literature that led to current clinical approaches.