Hospital admissions over weekends have been associated with worse outcomes in a variety of patient populations. The cause for this remains unclear. Authors of a recent study in the American Journal of Kidney Diseases investigated this question by examining the mortality of end-stage renal disease (ESRD) patients on weekends. They found that maintenance dialysis patients […]
Increasing attention has been given to preserved ejection fraction heart failure (HFPEF) in the general population, but little is known about this clinical entity in patients with end-stage renal disease. A recent study published in the American Journal of Kidney Diseases helps shed some light on the prevalence, clinical profiles, and long-term outcomes of peritoneal […]
Hyponatremia is a well-recognized complication of treatment with thiazide diuretics. Mechanisms include interference with maximal urinary dilution and stimulation of vasopressin release from mild volume depletion. Rodenburg et al have performed a population-based cohort study looking at the risk of hyponatremia in thiazide-treated patients living in a suburb of Rotterdam. A total of 13,325 patients […]
A recent article by Chandran et al published in the American Journal of Kidney Diseases describes a case of recurrent HIV-associated immune complex disease with lupus-like features following kidney transplantation. The following questions will test your knowledge on kidney transplantation and HIV-related kidney disease: 1. Finding the appropriate dose of calcineurin inhibitors (CNI) in a […]
In the recent study, “Patient and Caregiver Knowledge and Utilization of Partial Versus Radical Nephrectomy: Results of a National Kidney Foundation Survey to Assess Educational Needs of Kidney Cancer Patients and Caregivers,” published in the American Journal of Kidney Diseases, Russo et al report the results of a survey conducted by the National Kidney Foundation. […]
Invited commentary by Dr. Parmjeet Randhawa Pirkle et al recently reported an interesting case of lupus-like membranous nephropathy in the American Journal of Kidney Diseases. The pathologic features consistent with lupus nephritis were (a) the presence of IgG, IgM, IgA, C1q, and C3 deposits by immunofluorescence (so-called full-house pattern), (b) ultrastructural evidence of immune complex […]
Check out all of the coverage of this year’s American Transplant Congress by eAJKD’s Dr. Vinay Nair below: Alemtuzumab Induction and Belatacept-Based Immunosuppression in Kidney Transplant Recipients Eculizumab Therapy for Chronic Antibody Mediated Rejection The Impact of Pre-donation Weight Loss on Post-donation Outcome Does Adding Rituximab to IVIg and Plasmapheresis Improve Outcome of AMR? 1-Yr […]
Everolimus in Kidney Transplantation: HERAKLES trial Many studies have been conducted with the intention of reducing exposure to calcineurin inhibitors. Avoiding calcineurin inhibitors is expected to improve long term graft outcome by avoiding CNI nephrotoxicity. MTOR inhibitors (everolimus and sirolimus) have been used to minimize CNI exposure. Most studies reveal an improvement in GFR when […]
Simultaneous Liver Kidney Transplantation: Stealing or Saving? That was the topic of a hotly debated 3 lecture session presented by Dr. Nadim from the University of Southern California, Dr. Charlton from Mayo Clinic, and Dr. Levitsky from Chicago. Audience members included nephrologists, hepatologists, and surgeons among others. Here are a few key points that I […]
Pathology of Nephrotoxicity Associated With Monoclonal Antibody Therapy
In the June issue of the American Journal of Kidney Diseases, Sasaki et al report an interesting case of diffuse proliferative IgA-dominant immune complex glomerulonephritis in a patient who received cetuximab for recurrent oral squamous cell carcinoma. Establishing a cause and effect relationship between administration of a drug and the injury attributed to it is […]