miR-186 in FSGS: Entering a New Era in Biomarkers

The hunt for novel biomarkers for the diagnosis and monitoring of kidney diseases has intensified over the last decade, and several important advances are beginning to make their way into clinical medicine. Most notable is anti-PLA2R antibody testing for the diagnosis and monitoring of membranous nephropathy. In fact, a clinical test for anti-PLA2R antibodies was […]

CKD and Non-Alcoholic Fatty Liver Disease: Is There a Link?

Presentazione di PowerPoint

Targher et al recently published a review in AJKD that discussed the potential link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). We know the common causes of CKD include diabetes and hypertension; however, NAFLD is now being recognized as a possible cause. What is NAFLD? NAFLD is essentially an umbrella term […]

Trends in Polycystic Kidney Disease–Related CKD and ESRD

eAJKD

Autosomal dominant polycystic kidney disease (APKD) is the most common heritable cause of kidney disease with well-described genetics. A recent study published in AJKD describes the epidemiology and incidence trends of ESRD due to APKD in the US.  Dr. Scott Reule, the first author, discusses the study with Dr. Paul Phelan (eAJKD), eAJKD Contributor. eAJKD: […]

Somatomedins and the Kidneys

eAJKD

Insulin-like growth factors (IGF) are a group of peptides that include insulin and relaxins with a common structural feature of three disulfide bonds linking a variable and a domain chain. Indeed, they were named for this reason, having been previously labeled as ‘somatomedins’ based on their purported biological activity as mediators of the growth hormone […]

Pregnancy in IgA Nephropathy: A Blessing or Curse?

eAJKD

Kidney disease was historically considered a contraindication to pregnancy, and termination of pregnancy was often recommended. However, the data on successful outcomes in pregnant women with CKD are increasing. The first successful pregnancy in a dialysis patient was reported in 1971. In a recent study published in AJKD, Liu et al analyzed the impact of pregnancy […]

ORCID: What Physicians Need To Know…

Dr Matt Sparks ORCID profile

Have you ever tried to look up a colleague’s publication on PubMed, and found hundreds of J Smith’s? Or have you been cited in different forms by different publications?  Researchers, universities, and publishers have long sought a better way to identify and differentiate authors. Enter ORCID (Open Researcher and Contributor ID). What is ORCID? ORCID […]

Before and After TREAT

eAJKD

In a recent article published in AJKD, Thamer at al did a retrospective observational investigation of the ESA prescribing patters before and after publication of the TREAT trial, and even referred to TREAT as a “watershed” study. As erythropoietin rose to popularity, there was general agreement that blood transfusions are not indicated for Hgb > […]

Test Your Knowledge: Interstitial Nephritis

Interstitial Nephritis TYK - Question 1

In a recent article published in AJKD, Muriithi et al report a large series of 133 patients who had biopsy-proven acute interstitial nephritis at a single center. The following questions will test your pathology knowledge on this topic. Post prepared by and all images courtesy of Tibor Nadasdy, MD, eAJKD Contributor and AJKD Kidney Biopsy […]

Protein Carbamylation in Kidney Disease

Kalim et al AJKD Fig 1

A recent In Translation article by Kalim et al in AJKD reviews the clinical relevance of protein cabamylation in kidney disease. Carbamylation refers to the post-translational modification of proteins (other examples being phosphorylation and glycation) that occurs when adding a carbamoyl moiety (-CONH2) to amino acids. It is induced by exposure to urea and its […]

Test Your Knowledge: Anion Gap in Metabolic Acidosis

eAJKD

The serum anion gap is a common tool used in clinical practice. Recent advances have led to a new mnemonic GOLD MARK to differentiate the various causes of anion gap metabolic acidosis. A recent article in AJKD by Vichot and Rastegar discusses the use of anion gap in metabolic acidosis. The following questions will test […]

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