Happy New Year from AJKD!

Turning the calendar gives us the opportunity to look back on the top ten AJKDBlog posts of 2025.

Special thanks go out to the AJKDBlog Commentaries Editor, Pascale Khairallah, and Interviews Editor, Timothy Yau, and to all of our contributors!

Copyright: ibreakstock / Shutterstock

1. Urea for the Treatment of Hyponatremia 2/2 SIADH: An Interview Subhash Chander, interviewed by Tim Yau

PRISMA flow chart. Figure 1 from Chander et al, © National Kidney Foundation.

2. Renal Tubular Acidosis: An Interview Roger Rodby and William Whittier, interviewed by Tim Yau

The urine osmolar gap in states of appropriate ammonium excretion and ineffective ammonium excretion. Figure 3 from Bonner et al, © National Kidney Foundation.

3. Gout and CKD: Harmonizing Urate Control with Patient-Centric Care by Suzanne El-Sayegh, Hachem Araji, and Nadim Zaidan

Mean eGFR over all trial phases.  Figure 1 from Helget et al, © National Kidney Foundation.

4. Exploring the Optimal Blood Pressure Target in Advanced CKD by Nozaina Mahmood and Efren Chavez Morales

Frequency of primary and other adverse event outcomes of interest within the first 12 months of randomization Table 3 from Ku et al, © National Kidney Foundation.

5. Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD): An Interview Sara Jdiaa and Reem Mustafa, interviewed by Tim Yau

Indicators of Rapid ADPKD Progression That May be Used to Determine Eligibility for Tolvaptan TherapyTable 1 from Jdiaa et al, © National Kidney Foundation.

6. Statin Use in Chronic Kidney Disease: An Interview by Oshozimhede E. Iyalomhe, interviewed by Tim Yau

7. Viral Nephropathies: An Interview Anna Gaddy, Amy Yau, and Sangeetha Murugapandian, interviewed by Tim Yau

Example of collapsing secondary focal segmental glomerulosclerosis lesion in a patient with SARS-CoV-2 infection. Figure 1 from Yau et al, Image © 2024 Anjali A. Satoskar, MD and is reproduced with permission of the copyright holder.

8. Addressing Anemia in CKD and ESRD: Will Hypoxia-Inducible Factor Stabilization Eliminate the Need for Erythropoietin Stimulating Agents? by Diana Mahbod

Mechanism of action of HIF stabilizers. Figure 1 from Crugliano et al, © 2021 by the authors.

9. Genetic Testing Core Curriculum: An Interview Abraham W. Aron and Neera K. Dahl interviewed by Timothy Yau

Patient characteristics that increase the diagnostic yield of genetic testing. Figure 1 from Aron et al , © National Kidney Foundation.

10. Advanced Age Living Kidney Donation: How Old is Too Old? by Akshta Pai

BONUS Honorable Mentions:

• Uncovering the Unknowns in Nephrology by Becky Mingyao Ma
• Y SeX and Gender Differences Matter in CKD: Understanding the Impact on Kidney Function Decline by Jenny Pan

*Note: The Top Ten posts only include posts that published Nov 2024-Oct 2025 and do not include NephMadness posts.

2025 EDITORS’ CHOICE

The editors are delighted to recognize these articles that have been selected to receive the 2025 AJKD Editors’ Choice Award (all articles are freely available until February 1, 2026).