Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of diseases, is triggered by endothelial injury and/or dysfunction. In a recent Review published in AJKD, Dominique Suzanne Genest and colleagues reviewed the clinical presentation and pathologic hallmarks of renal-limited forms of TMA, disease-specific mechanisms that contribute to TMA lesions, diagnostic approach, and treatment strategies, and the potential role for emerging therapies.

AJKDBlog’s Interviews Editor Timothy Yau @Maximal_Change recently sat down with colleagues Anuja Java @anuja_java and Anna Vinnikova @KidneyWars to discuss these topics further.

If the embedded player above doesn’t work, please click here to watch the video interview. Special thanks to Drs. Java and Vinnikova for agreeing to do the interview!

Kidney histopathologic findings in acute thrombotic microangiopathy with mild chronic changes. Figure 2A from Genest et al, AJKD © National Kidney Foundation

To view this Review (Freely Available), please visit AJKD.org.

Title: Renal Thrombotic Microangiopathy: A Review
Author: Dominique Suzanne Genest, Christopher J. Patriquin,  Christoph Licht, Rohan John, and Heather N. Reich
DOI: 10.1053/j.ajkd.2022.10.014

Review articles cover clinical, translational, or basic science topics of interest to practitioners. Reviews published in the last two years are freely available.