TMA

#PathPointer: Tram-Tracking in a Transplant

January 30, 2019 // 0 Comments

The aesthetic qualities of a good Jones silver stain are underrated. The black linear pattern contrasting against the colors of the counterstained tissue evokes the lead borders and colored glass of stained-glass windows. But aside from their [read more...]

Thrombotic Microangiopathies and Stem Cell Transplant

October 17, 2018 // 0 Comments

A recent narrative review published in AJKD discusses the association between thrombotic microangiopathy (TMA) and hematopoietic stem cell transplantation (HSCT). AJKD Social Media Editor, Timothy Yau (AJKDBlog), interviewed two of the authors, [read more...]

I’ll Have A Gin and Tonic; Hold the Tonic

October 31, 2017 // 5 Comments

The gin and tonic is a classic cocktail, perfect with a sliver of lime on a hot summer day. But this simple-to-make drink also has a long-storied medical history that is credited with expanding and maintaining the British Empire for over a century. [read more...]

Thrombotic Microangiopathy in Cancer Patients

July 6, 2015 // 2 Comments

Thrombotic microangiopathy (TMA) describes a set of disorders that are characterized by microvascular thrombosis, microangiopathic hemolytic anemia, thrombocytopenia, and organ damage, most often to the kidney. Though TMA was classically divided [read more...]

SCM15: C4 Dense deposit Disease with TMA

March 26, 2015 // 2 Comments

Dr. Arshad Ali (AA), from Emory University School of Medicine in Atlanta, Georgia, discusses his abstract for the National Kidney Foundation’s 2015 Spring Clinical Meetings (SCM15), Proliferative C4 Dense Deposition Disease Concurrent with Acute [read more...]

Test Your Knowledge: Lupus Nephritis & Thrombotic Microangiopathy

January 12, 2015 // 1 Comment

In the January issue of AJKD, El-Husseini et al describe a case of lupus nephritis-associated thrombotic microangiopathy (TMA) that was successfully treated with eculizumab, a complement inhibitor. The following questions will test your knowledge on [read more...]

Eculizumab Can Be Discontinued in Selected Patients with aHUS

May 5, 2014 // 1 Comment

Since 2009, eculizumab has been successfully used for treatment of aHUS. What happens after discontinuation is less clear. Does the disease relapse? In a recent AJKD article, Ardissino et al review 10 cases of aHUS treated with eculizumab where the [read more...]

Factor H Deficiency and Atypical HUS

September 19, 2013 // 0 Comments

Atypical hemolytic uremic syndrome (aHUS) is characterized by excessive microvascular complement activation. Many mutations have now been described that lead to aHUS and its associated entity, C3 glomerulopathy. In a recent AJKD article, Wilson et [read more...]

Hematopoietic Stem Cell Transplantation–Related Kidney Injury

February 19, 2013 // 0 Comments

Hematopoietic stem cell transplantation (HSCT) exposes the kidney to a multitude of injuries, including acute kidney injury (AKI), hypertension, glomerular disease, and chronic kidney disease (CKD). A common pathology noted in most of these patients [read more...]

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Official Blog of the American Journal of Kidney Diseases

TMA