Early goal directed therapy (EGDT) is an early and aggressive treatment strategy for sepsis. There are 3 goals of therapy. 1. Increase the central venous pressure to 8-12 mm Hg with fluids. 2. Increase the MAP between 65-90 mm Hg with pressors or vasodilators. 3. Push the mixed venous oxygen saturation to over 70% with pRBC transfusion and inotropes. The landmark publication by Rivers et al in the NEJM in 2001 reported a ~35% reduction in mortality in sepsis. However, recent RCTs are beginning to question the effectiveness of EGDT in sepsis.