Early goal directed therapy (EGDT) is an early and aggressive treatment strategy for sepsis. There are 3 goals of therapy. 1. Increase the central venous pressure to 8-12 mm Hg with fluids. 2. Increase the MAP between 65-90 mm Hg with pressors or vasodilators. 3. Push the mixed venous oxygen saturation to over 70% with pRBC transfusion and inotropes. The landmark publication by Rivers et al in the NEJM in 2001 reported a ~35% reduction in mortality in sepsis. However, recent RCTs are beginning to question the effectiveness of EGDT in sepsis.
See the Current Standings! | For more on NephMadness 2015 | #NephMadness or #CCRegion on Twitter Critical care was a hotbed of controversy with no knock outs, all of the contests decided by a split decision of the voters. As a panelist said “No [read more...]
Kamran Boka, (@Boka_MD ) MD MS is a third-year pulmonary and critical care medicine fellow at Henry Ford Hospital, the cradle of EGDT. He is a board-certified internist, physician-educator, and active medical author. He hosts a blog [read more...]
Submit your picks! | For more on NephMadness 2015 | #NephMadness or #CCRegion on Twitter The critical care region is packed with interesting story lines, SLED was a bubble team that not many people thought would make the tournament but they [read more...]