Frailty is a multisystem syndrome of decreased physiologic reserve that has been shown to strongly and independently predict morbidity and mortality. Frailty is prevalent in patients living with kidney disease and occurs earlier in individuals with kidney disease as compared to the general population.  In a Review recently published in AJKD, Nair and colleagues examine clinical and research applications of frailty in kidney disease populations.

Sample schema of frailty progression showing areas of overlap between age, multimorbidity, frailty, and disability. Events may not occur in a linear progression, and frailty is not an inevitable sequela of chronologic aging or living with multimorbidity. Dotted line represents a threshold after which individual can no longer return to a robust health state. Figure 1 from Nair et al, © National Kidney Foundation.

AJKDBlog’s Interviews Editor, Timothy Yau (@Maximal_Change), sat down with Drs. Devika Nair (@devimol), Rasheeda Hall (@Rasheeda_HallMD), and Christine Liu (@DocForGrandma) to discuss why frailty measurements matter in the care of patients with kidney disease.

If the embedded player above doesn’t work, please click here to watch the video interview. For access to the Kidney Disease Aging Research Collaborative (KDARC) mentioned at the end of the video by Dr. Hall, click here. Special thanks to Drs. Nair, Hall, and Liu for their time and insight!

To view this Review by Nair et al [FREE], please visit AJKD.org:

Title: Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications
Authors: Devika Nair, Christine K. Liu, Rasha Raslan, Mara McAdams-DeMarco, and Rasheeda K. Hall DOI:  10.1053/j.ajkd.2024.04.018

Review articles cover clinical, translational, or basic science topics of interest to practitioners. Reviews are freely available at AJKD.org.