Renal tubular acidoses (RTAs) are a subset of non-anion gap metabolic acidoses that result from complex disturbances in renal acid excretion.  In a Core Curriculum recently published in AJKD, Ryan Bonner and Gerald Hladik discuss the disturbances that can lead to the development of metabolic acidosis and/or a failure to compensate fully for other systemic acidoses.

The urine osmolar gap in states of appropriate ammonium excretion and ineffective ammonium excretion. Figure 3 from Bonner et al, © National Kidney Foundation.

AJKDBlog’s Interviews Editor, Timothy Yau (@Maximal_Change) sat down with Drs. Roger Rodby (@NephRodby) and William Whittier (@TWhittier_RUSH) to discuss physiology, treatment, and to delve into thoughts on the urinary anion gap.

If the embedded player above doesn’t work, please click here to watch the video interview. Special thanks to Drs. Rodby and Whittier for their time and insight!

To view this Original Investigation by Bonner et al [FREE], please visit AJKD.org:

Title: Renal Tubular Acidosis: Core Curriculum 2025
Authors: Ryan Bonner and Gerald Hladik
DOI: 10.1053/j.ajkd.2024.08.014

Core Curricula aim to give trainees in nephrology a strong knowledge base in core topics in the specialty by providing an overview of the topic and citing key references, including the foundational literature that led to current clinical approaches. All Core Curricula are freely available on AJKD.org