APOL12015
The APOL1 risk alleles, G1 and G2, are mutually exclusive (never occur on the same chromosome copy) and 2 copies are necessary to confer kidney disease risk (genotype may be G1/G1, G2/G2, or the compound heterozygous state of G1/G2). Variation in these alleles is now known to be responsible for the vast majority excess risk of non-diabetic kidney disease including FSGS, HIV-associated nephropathy, and unspecified CKD in African Americans.
Barry I. Freedman, MD, FACP is John H. Felts, III Distinguished Professor and Chief, Section on Nephrology at Wake Forest School of Medicine. His research focuses on
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David Friedman, MD, is a nephrologist at Beth Israel Deaconess Medical Center and an assistant professor at Harvard Medical School. His laboratory studies the genetics of
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