In the 2015 NephMadness tournament, I’m looking for this year’s “Kentucky”- the pick that, if you were a betting woman/man, would be the team to beat. My overall #1 team in this year’s NephMadness is APOL1. The strength of the association between having high-risk APOL1 gene variants and the development of progressive renal disease and ESRD is a groundbreaking discovery in explaining why black patients carry an increased risk for CKD. While the mechanism of this association is not clear, the public health implications of such a discovery are enormous for patients and physicians alike. Just like Kentucky, APOL1 is undefeated, with each manuscript strengthening the case that it is a force to be reckoned with in CKD and the 2015 NephMadness Tournament!
Jonathan Hogan, MD
Hospital of the University of Pennsylvania
Clinical Director, Glomerular Disease Program
Think he’s right? Think he has cerebral venous sinus thrombosis? Make your call by entering your picks in NephMadness 2015.