Norepinephrine is a catacholamine that acts on both α1 and α2 adrenergic receptors primarily in vascular smooth muscle cells leading to systemic vasoconstriction. The Surviving Sepsis campaign lists norepinephrine as the first-line vasopressor for hemodynamic instability in sepsis with an evidence grade of 1B. Norepinephrine, through it effects primarily at increasing peripheral vascular resistance, leads to less tachycardia and arrhythmia. Moreover, randomized trials have supported its use as a first line agent in sepsis.