NephMadness 2015: Critical Care Nephrology Region
Submit your picks! | For more on NephMadness 2015 | #NephMadness or #CCRegion on Twitter The critical care region is packed with interesting story lines, SLED was a bubble [...]
NorepinephrineinSepsis
Norepinephrine is a catacholamine that acts on both α1 and α2 adrenergic receptors primarily in vascular smooth muscle cells leading to systemic vasoconstriction. The Surviving Sepsis campaign lists norepinephrine as the first-line vasopressor for hemodynamic instability in sepsis with an evidence grade of 1B. Norepinephrine, through it effects primarily at increasing peripheral vascular resistance, leads to less tachycardia and arrhythmia. Moreover, randomized trials have supported its use as a first line agent in sepsis.