Oncology has seen a rapid expansion in the use of targeted therapy directed against cancer-specific molecules and signaling pathways. Tyrosine kinases are an especially important target because they play an important role in the modulation of growth factor signaling. Examples of tyrosine kinase inhibitors (TKI) are sunitinib, sorafenib, axitinib, and pazopanib. These not only inhibit VEGF, but also have inhibitory activity against other receptor tyrosine kinases, such as the platelet-derived growth factor receptor or cKit. However, a number of renal specific side effects are increasing being recognized. These include thrombotic microangiopathy, acute and chronic interstitial nephritis, and hypophosphatemia.
The Final Four Sudden Cardiac Death in ESRD vs Furosemide Stress Test Winner: Sudden Cardiac Death in ESRD 4-3 split With the narrowest of margins Team Sudden Cardiac Death in ESRD marches on to the Final Four of NephMadness. Furosemide Stress Test [read more...]
The Elite 8 is the final four of our tournament. In the NCAA tournament the final four represent the four regional winners. In NephMadness the Elite eight represent the 8 winners of each named region. Here we will get the Heart and Kidney Connection [read more...]
Nephron Sparing Surgery vs Tyrosine Kinase Inhibitor Toxicity Winner: Tyrosine Kinase Inhibitor Toxicity 4-3 split In another narrow victory, Team Tyrosine Kinase moves to the sweet 16. A comment from the blue-ribbon panel (BRP) sums it up: [read more...]
See the Current Standings! | For more on NephMadness 2015 | #NephMadness or #OncoRegion on Twitter Nephron-Sparing Surgery versus Nephrectomy for Renal Cancer Winner: Nephron-Sparing Surgery 6-1 split Taking the kidney out and curing the cancer is a [read more...]
Submit your picks! | For more on NephMadness 2015 | #NephMadness or #OncoRegion on Twitter Onconephrology is wide subject ranging from renal cancers, to side effects from chemo- and radiotherapy to renal paraneoplastic processes like amyloidosis. [read more...]