Word Search: IgA Nephropathy

In the December 2011 issue of American Journal of Kidney Diseases, Jurgen Floege discusses the novel development of pathogenesis of IgA Nephropathy. Test your knowledge with a word search. Clues to the answers are listed below the puzzle. The answers may be horizontal, vertical, diagonal or in reverse order.

S L A M B D A H H M Y C S P R
E U R T E N I N E S I U Y I A
H O C N X N E S K T L C N H S
E L D C G O A P A I E U D N V
M E A E O N M M H J K C R H T
A I H D G C O P B R P M O Q K
T M I I Q T O W G U O I M E R
U S U Y P M M L M N I T E C C
R M O M E N N X Y D B J I N C
I X Y A C E L L S H U N P C E
A S H W R D Y V N V P K F H F
A D E T A L Y S O T C A L A G
W K V W L E H D N F N S T I D
N V N T Y U C B D Y T D G S P
B G K H M R E P L E H P S N U
  1. Most patients with IgA nephropathy are clinically _____________(12)
  2. The most common loci associated with susceptibility to IgA nephropathy in British patients(5)
  3. Not the endothelium, not the epithelium, but the __________ (9)
  4. The single best established factor responsible for driving proliferation of mesangial cells in IgA nephropathy (4) (abbrv)
  5. IgA nephropathy is far more common in high socioeconomic groups like Japan, Northern Europe compared with _________ (4) , which is more common in low socio economic groups.
  6. This genus of bacteria is associated with development of IgA nephropathy (14)
  7. One of the reasons its hard to study IgA nephropathy in mice is because mice, unlike humans, lack an IgA ______(5) region.
  8. Patients with elevated circulating levels of IgA and mesangial deposits of secretory IgA most commonly present with _________( 9)
  9. IgA deposited in the glomerulus is most commonly composed of this light chain (5).
  10. The best known finding in IgA nephropathy is an elevation in circulating poorly __________________(14) IgA1 O-glycoforms.

For the answers to the word search click here.

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