glomerular diseases

Test Your Knowledge: Lupus Nephritis & Thrombotic Microangiopathy

January 12, 2015 // 1 Comment

In the January issue of AJKD, El-Husseini et al describe a case of lupus nephritis-associated thrombotic microangiopathy (TMA) that was successfully treated with eculizumab, a complement inhibitor. The following questions will test your knowledge on [read more...]

Podocyturia in Healthy Individuals Shows Markers of De-differentiation

December 8, 2014 // 0 Comments

The podocyte has emerged as the focus of intense investigation for kidney researchers. This cell is located at the key transition point in the glomerulus where the plasma is filtered through the basement membrane to enter the urinary space to begin [read more...]

Hantavirus Infection Presenting with Acute Reversible Podocytopathy

July 24, 2014 // 0 Comments

Hantavirus is a genus of the virus family Bunyaviridae, has manysub-species, and is endemic in several parts of the world. Human disease is caused by viral transmission from the excreta of infected rodents. Outside of endemic areas, which may be [read more...]

Membranous Nephropathy with Crescents

June 5, 2014 // 0 Comments

While membranous nephropathy (MN) is one of the most common forms of nephrotic syndrome in adults, it is rarely associated with the pathologic finding of crescents on kidney biopsy. Most reported cases are in the context of concomitant [read more...]

Eculizumab Can Be Discontinued in Selected Patients with aHUS

May 5, 2014 // 1 Comment

Since 2009, eculizumab has been successfully used for treatment of aHUS. What happens after discontinuation is less clear. Does the disease relapse? In a recent AJKD article, Ardissino et al review 10 cases of aHUS treated with eculizumab where the [read more...]

Common Pitfalls in Lupus Nephritis

February 24, 2014 // 0 Comments

Bose, Silverman, and Bargman provide an excellent summary of common mistakes and misconceptions about the treatment of lupus nephritis. Their list of the 10 most common mistakes serves as an excellent treatment guide for both the novice and [read more...]

Test Your Knowledge: Proliferative Glomerulonephritis

February 20, 2014 // 0 Comments

Proliferative glomerulonephritis (GN) is defined as an increase in glomerular cellularity due to the influx of leukocytes and/or the proliferation of native cells. There are four major light microscopy patterns of proliferative GN – mesangial, [read more...]

#DreamRCT: Creation of an International Glomerular Disease Trial Network (iGDTN)

February 15, 2014 // 5 Comments

The DreamRCT is a great online project spearheaded by Jordan Weinstein at UKidney and Joel Topf at PBFluids. Nephrology bloggers from WhizBang, Nephron Power, Renal Fellow Network, PBFluids, UKidney, Ed El Sayed and Swapnil Hiremath are pitching [read more...]

Lupus Nephritis: A 2014 Treatment Update

February 6, 2014 // 1 Comment

In the recent review “Lupus Nephritis: the Evolving Role of Novel Therapeutics” published in AJKD, Rovin and Parikh summarize the current understanding of the pathogenesis of lupus nephritis (LN) and review the novel agents under study for [read more...]

Guidelines for Kidney Diseases

August 8, 2013 // 0 Comments

In 2012, Kidney International Supplements published the KDIGO guidelines on the treatment of glomerular diseases (GN). The guidelines were commissioned as part of a KDIGO workgroup that looked at evidence-based data in glomerular diseases. GN is a [read more...]

AJKD Blog

Official Blog of the American Journal of Kidney Diseases