sFlt1inPreeclampsia
sFlt1 levels increase before and during the advent of signs and symptoms of preeclampsia. sFlt1 is a splice variant of vascular endothelial growth factor receptor 1 (VEGF-R1) and is capable of acting as a molecular sink to decrease active VEGF and placental growth factor (PIGF). Animal models suggest that sFlt1 plays a pivotal role in the pathogenesis of preeclampsia. Studies using apheresis to lower sFlt1 levels in patients are currently underway.
S. Ananth Karumanchi, MD is a Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School, Boston. He currently works as an attending physician
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