In the December issue of the American Journal of Kidney Diseases, Dy et al discuss an association of central diabetes insipidus with acute myelogenous leukemia (AML). Central diabetes insipidus is a condition that may be due to many other causes. The following questions will test your knowledge on central diabetes insipidus.
1. Which of the following is not a congenital cause of central diabetes insipidus?
A. Wolfram syndrome
B. Septo-optic dysplasia
C. Posterior pituitary ectopia
D. Langerhans cell histiocytosis
2. Which of the following is not considered a treatment for central diabetes insipidus?
3. All of the following can suppress anti-diuretic hormone (ADH) secretion leading to central diabetes insipidus except…
A. Anorexia nervosa
D. Lung (small cell) cancer
E. Prolonged cardio-pulmonary arrest
4. Which of the following scenarios is most consistent with the diagnosis of central diabetes insipidus?
A. An increase in urine osmolality from 250 to 500 mOsmol/kg after an overnight water restriction in a patient on phenothiazone therapy, which changes minimally after desmopressin administration.
B. An increase in serum sodium from 138 to 149 mmol/L after overnight water restriction, with an AM urine specific gravity of <1.005 that rises to 1.030 after administration of desmopressin.
C. An increase in urine osmolality from 200 to 240 mOsmol/kg after administration of desmopressin in a patient on chronic lithium therapy with serum sodium level of 151 mmol/L.
Post prepared Dr Aditya Kadiyala, Nephrology Fellow from Hofstra NSLIJ School of Medicine, and Kenar D. Jhaveri, eAJKD blog editor.
To see answers, please click here.