Clonal hematopoiesis of indeterminate potential (CHIP), defined by the age-related ontogenesis of expanded leukemogenic variants indicative of a genetically distinct clonal leukocyte population, is associated with risk of hematologic malignancy and cardiovascular disease. In a recent study published in AJKD, Bryan Kestenbaum et al., tested the hypothesis that CHIP is associated with kidney function decline in the general population.
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Title: Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population
Author: Bryan Kestenbaum, Alexander Bick, Caitlyn Vlasschaert, Michael Rauh, Matthew Lanktree, Nora Franceschini, Moore Shoemaker, Raymond Harris Jr., Bruce Psaty, Anna Köttgen, Pradeep Natarajan, and Cassianne Robinson-Cohen.