Sethi

Eculizumab Can Be Discontinued in Selected Patients with aHUS

May 5, 2014 // 1 Comment

Since 2009, eculizumab has been successfully used for treatment of aHUS. What happens after discontinuation is less clear. Does the disease relapse? In a recent AJKD article, Ardissino et al review 10 cases of aHUS treated with eculizumab where the [read more...]

Test Your Knowledge: Renal Replacement Therapy in Children

April 18, 2014 // 0 Comments

There is paucity of literature on dialysis in the pediatric population, especially on prescription and complications. Since renal replacement therapy in children requires specialized care, Sethi et al discuss these issues in a Core Curriculum [read more...]

Factor H Deficiency and Atypical HUS

September 19, 2013 // 0 Comments

Atypical hemolytic uremic syndrome (aHUS) is characterized by excessive microvascular complement activation. Many mutations have now been described that lead to aHUS and its associated entity, C3 glomerulopathy. In a recent AJKD article, Wilson et [read more...]

Socioeconomic Status, Kidney Disease in Children

September 9, 2013 // 0 Comments

Among adults, lower socioeconomic status (SES) is a risk factor for chronic kidney disease (CKD), progression to end-stage renal disease, and poor health outcomes. However, the effect among children with CKD is not well known. The Chronic Kidney [read more...]

Recap of eAJKD’s coverage of the Pediatric AKI/CRRT 2012 Conference

October 2, 2012 // 0 Comments

Check out all of the coverage of this year’s 1st International Symposium on AKI in Children at the 7th International Conference on Pediatric Continuous Renal Replacement Therapy by eAJKD’s Sidharth Sethi below: The Opening Day Incidence of AKI [read more...]

Pediatric AKI/CRRT 2012 Conference: New studies in pediatric nephrology

October 1, 2012 // 1 Comment

Important Posters – topics From Cincinnati, KIM-1 as an emerging biomarker for cardio-renal syndrome in dilated cardiomyopathy in children MARS in children awaiting liver transplant from Netherlands KIDS-CRRT device from Georgia Tech [read more...]

Pediatric AKI/CRRT 2012 Conference: Interesting Observations

October 1, 2012 // 1 Comment

AKI can worsen pneumonia in-vitro In vitro showed suggest that acute kidney injury (AKI) limit the amount of pulmonary polymorphonuclear cell (PMN) recruitment during pneumonia and worsened pneumonia. Mice with AKI and pneumonia had lower [read more...]

Pediatric AKI/CRRT 2012 Conference: Novel therapies and studies in AKI

September 30, 2012 // 2 Comments

Novel therapies mentioned at the conference for acute kidney injury (AKI) in future p53 si RNA Deferipone Alpha MSH Mesenchymal stem cells Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium. [read more...]

Pediatric AKI/CRRT 2012 Conference: Biomarkers in AKI

September 30, 2012 // 2 Comments

Biomarkers Dr Devarajan calls the panel “NGAL, IL-18, KIM-1 and L-FABP” as Super Four of the markers of acute kidney injury (AKI) diagnosis. Urine NGAL represents NGAL liberated FROM the kidney, and is not seen in pre-renal insults. Recent TRIBE [read more...]

Pediatric AKI/CRRT 2012 Conference: Incidence of AKI

September 30, 2012 // 1 Comment

About the Conference The PCRRT conference has been renamed as the PCRRT/P-AKI to include both the treatment and the pathophysiology of Pediatric acute kidney injury (AKI). There are still multiple definitions of AKI and there is a need to have a [read more...]

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