2022 Editors’ Choice Award

In 2017, we established an annual celebration of articles that our editorial team designated as “Editors’ Choice” selections. The editors are delighted to recognize the articles listed below that have been selected to receive the 2022 Editors’ Choice Award. These articles will be freely available at AJKD.org until January 31, 2023. Congratulations to all the authors!


Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis by Edmund Y.M. Chung, Suetonia C. Palmer, Patrizia Natale, Anoushka Krishnan, Tess E. Cooper, Valeria M. Saglimbene, Marinella Ruospo, Eric Au, Sumedh Jayanti, Amy Liang, Danny Jia Jie Deng, Juanita Chui, Gail Y. Higgins, Allison Tong, Germaine Wong, Armando Teixeira-Pinto, Elisabeth M. Hodson, Jonathan C. Craig, and Giovanni F.M. Strippoli (December 2021) [FREE]

Image from Pixabay / Gerald

From the authors: Previous studies suggest that people with chronic kidney disease (CKD) may be severely affected by coronavirus disease 2019 (COVID-19). We searched for observational studies that investigated how many people with CKD were diagnosed with COVID-19 and experienced related health outcomes, including death, respiratory failure, and need for dialysis. Data were pooled from 348 studies that included a total of more than 1 million people with CKD. COVID-19 occurred more commonly in people who required long-term dialysis than in those with CKD not requiring dialysis (including kidney transplant recipients). People with CKD and COVID-19 may have a 10-fold higher risk of death than people with CKD without COVID-19.

DOI: 10.1053/j.ajkd.2021.07.003

Editorial Understanding the Burden of the COVID-19 Pandemic for People With Kidney Disease by James Wetmore [FREE]

Impact of Bioelectrical Impedance–Guided Fluid Management and Vitamin D Supplementation on Left Ventricular Mass in Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial by K. Scott Brimble, Javier Ganame, Peter Margetts, Arsh Jain, Jeffrey Perl, Michael Walsh, Jackie Bosch, Salim Yusuf, Samy Beshay, Winnie Su, Deborah Zimmerman, Shun Fu Lee, and Azim S. Gangji (June 2022)

Table 5 from Brimble et al, AJKD © National Kidney Foundation

From the authors: Patients on peritoneal dialysis have a high risk of cardiovascular events and increased left ventricular mass. They are also at significant risk of fluid overload and vitamin D deficiency, which may have detrimental effects on cardiac structure. We conducted a randomized controlled trial to determine if using bioimpedance analysis, a technology to assess volume status, or vitamin D supplementation reduces left ventricular mass. We found that using bioimpedance analysis and vitamin D supplementation had a potentially beneficial effect on fluid overload and improved vitamin D levels but did not have a beneficial effect on left ventricular mass. These findings do not support the use of bioimpedance analysis or vitamin D supplementation to prevent or reduce left ventricular hypertrophy.

DOI: 10.1053/j.ajkd.2021.08.022

SGLT2 Inhibitors and the Risk of Acute Kidney Injury in Older Adults With Type 2 Diabetes by Min Zhuo, Julie M. Paik, Deborah J. Wexler, Joseph V. Bonventre, Seoyoung C. Kim, and Elisabetta Patorno (June 2022)

From the authors: Sodium-glucose cotransporter 2 (SGLT2) inhibitors, dipeptidyl peptidase 4 inhibitors, and glucagon-like peptide 1 receptor agonists are 3 newer classes of glucose-lowering medications to treat type 2 diabetes. The beneficial effects of SGLT2 inhibitors extend beyond glycemic control and include reduction in cardiovascular events, kidney disease progression, and mortality. However, there was a concern that SGLT2 inhibitors might increase the risk of acute kidney injury. In this nationwide study using Medicare data, we found that the initiation of an SGLT2 inhibitor was associated with a lower risk of acute kidney injury compared with initiation of a dipeptidyl peptidase inhibitor or a glucagon-like peptide 1 receptor agonist among matched older adults with type 2 diabetes. Our results add to the available evidence on the safety profile of SGLT2 inhibitors in older adults.

DOI: 10.1053/j.ajkd.2021.09.015

Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis by Kalathil K. Sureshkumar, Bhavna Chopra, Michelle A. Josephson, Pratik B. Shah, and Rita L. McGill (October 2021)

From the authors: Patients with kidney disease, like all other Americans, struggle with obesity. Patients with obesity have improved survival after kidney transplantation compared with continued maintenance dialysis. Many transplant centers limit the eligibility of patients with body mass index (BMI) >35 kg/m2 for kidney transplantation because of safety concerns. We examined patient and transplant outcomes among recipients with BMI >35 kg/m2 versus recipients with BMI 18-25 (ie, nonobese), >25-30, and >30-35 kg/m2. Neither patient survival nor hospital length of stay differed across BMI categories. Delayed graft function was more common when BMI was >35 kg/m2. Death-censored graft failure was greater among the groups with BMI >30 kg/m2compared with the nonobese groups. Our results suggest that strict BMI criteria for kidney transplantation may deserve reconsideration.

DOI: 10.1053/j.ajkd.2021.02.332

Editorial Kidney Transplantation and Candidate BMI: Viability Is in the Eye of the Beholder by Anne M. Huml and Jesse D. Schold [FREE]

Epidemiology and Risk Factors for Hemodialysis Access–Associated Infections in Children: A Prospective Cohort Study From the SCOPE Collaborative by Rebecca L. Ruebner, Heidi Gruhler De Souza, Troy Richardson, Badreldin Bedri, Olivera Marsenic, Franca Iorember, Jillian K. Warejko, Bradley A. Warady, and Alicia M. Neu (August 2022)

From the authors: Dialysis access–associated infections are a major cause of morbidity and death among children receiving maintenance hemodialysis (HD). The Standardizing Care to Improve Outcomes in Pediatric End-Stage Kidney Disease (SCOPE) Collaborative is a multicenter quality-improvement initiative aimed at reducing dialysis-associated infections through implementation of standardized care practices. In this study of 1,277 children receiving HD at 35 pediatric dialysis centers, risk factors for catheter-associated bloodstream infections included mupirocin use or no antibiotic agent use at the catheter exit site. Dialysis centers that demonstrated improved adherence to SCOPE HD care practices over time had a significant reduction in catheter-associated bloodstream infection rates. Consistent improvement in compliance with standardized HD care practices can lead to a reduction in the risk of dialysis-associated infections.

DOI: 10.1053/j.ajkd.2021.11.008


“Recognizing research published in AJKD that has great promise to enhance the lives of those affected by kidney disease”

Advance Care Planning Coaching in CKD Clinics: A Pragmatic Randomized Clinical Trial (May  2020)

by Dale E. Lupu, Annette Aldous, Elizabeth Anderson, Jane O. Schell, Hunter Groninger, Michael J. Sherman, Joseph R. Aiello, and Samuel J. Simmens

From the authors: Advance care planning (ACP) is key to incorporating patient preferences into decisions regarding future health care. Studies have described successful approaches to incorporating ACP into dialysis care, but none had investigated implementation of ACP earlier in the course of chronic kidney disease—an approach recommended by patients. This pragmatic randomized trial enrolled 254 patients at 3 chronic kidney disease clinics and used ACP “coaching” through a program called Make Your Wishes About You (MY WAY). Based on motivational interviewing, MY WAY provides a flexible approach to elicit and document patient goals and preferences. Patients who received coaching were 79% more likely to have an advance directive in their clinic chart and scored 1.9 points higher on an engagement measure, although this effect of MY WAY was only observed at 1 of the 3 clinical study sites.

DOI: 10.1053/j.ajkd.2021.08.019

Blog Post Measuring the Success of Advanced Care Planning Implementation in Chronic Kidney Disease Clinics: The Importance of Organizational Readiness by Lachlan McMichael [FREE]


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