#KidneyWk 2016: Fellows’ Knowledge Competition

This year’s Nephron Challenge (aka Nephrology Jeopardy) was moderated by Dr. James Simon from the Cleveland Clinic. 3 teams of 4 fellows competed against each other with standard “Jeopardy” style rules, with points awarded for correct responses and points deducted for incorrect responses. This year’s winning fellow team hailed from University of Arkansas. Congratulations to them and all the participants this year!

Here are a few sample questions from the session. Test your knowledge recall, and jump to the bottom to see the answers.

  1.  This toxic ingestion is the most likely cause of high serum osmolal gap associated with normal arterial pH, normal anion gap, positive urine ketones, and falsely elevated serum creatinine.
  2. Hypokalemia with resistant hypertension that responds to spironolactone despite suppressed aldosterone levels should make you think of this monogenic cause of secondary hypertension.
  3. This acid-base disorder is associated with calcium phosphate stones, normal serum bicarbonate, urinary pH > 5.3 after an acid load, and hypocitraturia.
  4. Mutations in the gene that encodes this tight junction protein is the major cause of the syndrome of familial hypomagnesemia with hypercalciuria and nephrocalcinosis.
  5. Medications that break disulfide bonds are used to treat this type of kidney stone.
  6. Present in types I, II, IV, and V of this autosomal recessive disorder, hyperprostaglandin syndrome leads to polyhydramnios, polyuria, hypercalciuria, and nephrocalcinosis.
  7. This inorganic compound, added to municipal water systems to prevent bacterial overgrowth, can cause hemolytic anemia in hemodialysis if not removed during the water treatment process.
  8. Until recent decades, this 19th century nephrologist had the disease named after him that described the general presentation of acute nephritis.
  9. This surgeon performed the first successful human kidney transplant in 1954. He was co-recipient of the Nobel Prize in Medicine in 1990.
  10. FINAL JEOPARDY QUESTION! A close friend of JRR Tolkien, this author of the Chronicles of Narnia and The Screwtape Letters woke up from a coma after receiving his last rites, only to die later that year of kidney failure at the age of 64.

Scroll down for answers!









  1. Isopropyl alcohol
  2. Syndrome of Apparent Mineralocorticoid Excess
  3. Incomplete distal RTA
  4. Claudin-16 (paracellin 1)
  5. Cystine stones
  6. Bartter’s Syndrome
  7. Chloramines
  8. Richard Bright
  9. Joseph Murray
  10. C.S. Lewis

Posted by Dr. Timothy Yau, M.D.
Washington University School of Medicine, Division of Nephrology, St. Louis, MO
Live from Chicago, Illinois at the 50th ASN, #KidneyWk 2016

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