Randhawa – AJKD Blog

Kidney Transplantation in Identical Twins

November 28, 2018 // 1 Comment

A young man who had an identical twin donor was recently transplanted. The cause of end-stage disease was IgA nephropathy. The donor had no renal dysfunction or proteinuria. There was no demonstrable HLA mismatch. The panel reactive antibody (PRA) [read more...]

Changes in ISN/RPS Classification of Lupus Nephritis

June 22, 2018 // 2 Comments

The renal biopsy plays an important part in the management of systemic lupus erythematosus. It helps determine the most appropriate initial therapy and provides prognostic information. It also plays an important part in documenting ongoing [read more...]

Glomerulitis Without Evidence of Antibody-Mediated Rejection

February 23, 2018 // 0 Comments

PathPointers is a new type of blog post that will highlight important everyday teaching points when reviewing kidney histology. These blog posts will be brief and easy-to-read, using real clinical images to demonstrate various biopsy findings. In [read more...]

Role of Donor Pre-Implantation Biopsies in Kidney Transplantation

November 22, 2017 // 0 Comments

PathPointers is a new type of blog post that will highlight important everyday teaching points when reviewing kidney histology. These blog posts will be brief and easy-to-read, using real clinical images to demonstrate various biopsy findings. In [read more...]

Unexpected Pathology in a Post-Transplantation Protocol Biopsy

August 29, 2017 // 0 Comments

PathPointers is a new type of blog post that will highlight important everyday teaching points when reviewing kidney histology. These blog posts will be brief and easy-to-read, using real clinical images to demonstrate various biopsy findings. In [read more...]

C4 Glomerulopathy: Should We Accept it As a New Disease?

February 29, 2016 // 0 Comments

A recent article published by AJKD reports 3 patients with nephrotic syndrome, two of whom also had hematuria. Kidney biopsy revealed mesangioproliferative glomerulonephritis in one case, membranoproliferative glomerulonephritis in the second [read more...]

Transplacental Transmission of Autoimmune Glomerular Disease

February 11, 2016 // 0 Comments

In a recent article in AJKD, Al-Rabadi et al present a case of a pregnancy patient with active membranous nephropathy (MN) and circulating autoantibodies to PLA2R, the major autoantigen in primary MN. Despite the presence of low titer circulating [read more...]

Practical Tips for the Diagnosis of Acute Antibody-Mediated Rejection

December 28, 2015 // 1 Comment

A recent installment of the AJKD Atlas of Renal Pathology II gives a succinct summary of the morphologic criteria that may be used to diagnose acute antibody-mediated rejection (ABMR) in the allograft kidney. The following points should be kept in [read more...]

Acute and Chronic Antibody-Mediated Rejection Represent a Continuum of Endothelial Injury Involving Multiple Immune Mechanisms

December 21, 2015 // 0 Comments

A comparison of the criteria for acute and chronic antibody-mediated rejection (ABMR) in the November installment of the AJKD Atlas of Renal Pathology II shows that only criterion 1, which refers to histologic evidence of chronic tissue injury, is [read more...]

Focal Segmental Glomerulosclerosis: Sampling Error in Misdiagnosis

September 3, 2015 // 0 Comments

The term “focal” is an integral part of the nomenclature of focal segmental glomerulosclerosis (FSGS). Therefore, since not all glomeruli are affected, sampling error is an inherent problem in the pathologic diagnosis of FSGS. Estimating the [read more...]