pathology

Light Chain Proximal Tubulopathy – The Tip of the Iceberg?

November 8, 2016 // 1 Comment

In recent years, there has been increased recognition of the spectrum of kidney diseases associated with paraproteinemias. The fact that the pathogenetically related categories of “monoclonal immunoglobulin deposition disease” and “light chain [read more...]

C4 Glomerulopathy: Should We Accept it As a New Disease?

February 29, 2016 // 0 Comments

A recent article published by AJKD reports 3 patients with nephrotic syndrome, two of whom also had hematuria. Kidney biopsy revealed mesangioproliferative glomerulonephritis in one case, membranoproliferative glomerulonephritis in the second [read more...]

Congenital Nephrotic Syndrome: Finnish Type or Diffuse Mesangial Sclerosis?

September 21, 2015 // 0 Comments

Both congenital nephrotic syndrome of Finnish type (CNF) and diffuse mesangial sclerosis (DMS) represent major histopathologic patterns resulting in congenital nephrotic syndrome associated with genetic defects. CNF typically results from germline [read more...]

Recurrent and De Novo FSGS Following Kidney Transplantation

September 14, 2015 // 1 Comment

Atlas Fogo et al Collapsing Glomerulopathy Fig 2

Recurrent FSGS Incidence: 20-40% Risk factors: Childhood onset, rapid progression, recurrence of FSGS in prior transplant Clinical Features: Nephrotic syndrome within weeks after transplantation. Also, can have hematuria, hypertension, and AKI [read more...]

AJKD Atlas of Renal Pathology II: The Ultimate Pathology Teaching Tool Has Arrived

August 24, 2015 // 2 Comments

Dr. Agnes Fogo (AF; @AgnesFogo) does not need an introduction. For nephrologists, nephrology fellows, and nephropathology residents around the world, her AJKD Atlas of Renal Pathology has long been a valuable resource. Dr Fogo is currently the John [read more...]

Test Your Knowledge: HIV and The Kidney

May 4, 2015 // 1 Comment

In an article published in AJKD, Lum et al describe a case of acute kidney injury in a patient with well-controlled HIV infection on highly active anti-retroviral therapy (HAART). The following questions will test your pathology knowledge on [read more...]

Drug Abusers and Kidney Disease: A Pathologist Perspective

May 22, 2014 // 2 Comments

The autopsy study of Buettner et al provides very interesting data on kidney changes in illicit drug abusers who underwent forensic autopsy following drug-related death. This cross-sectional autopsy study provides relevant and somewhat surprising [read more...]

Test Your Knowledge: Proliferative Glomerulonephritis

February 20, 2014 // 0 Comments

Proliferative glomerulonephritis (GN) is defined as an increase in glomerular cellularity due to the influx of leukocytes and/or the proliferation of native cells. There are four major light microscopy patterns of proliferative GN – mesangial, [read more...]

Nephropathology: A Nephrologist’s Perspective

May 9, 2013 // 1 Comment

Invited commentary by Dr. Vivekanand Jha D’Agati and Mengel provide a fascinating account of the history of kidney pathology over last 60 years. As they note, it is impossible to imagine nephrology as it exists today without acknowledging the [read more...]

Nephropathology: A Pathologist’s Perspective

May 7, 2013 // 0 Comments

Drs. D’Agati and Mengel provide an excellent review on the history and evolution of kidney pathology. The article clearly highlights how the important contributions of nephropathologists have improved our understanding of kidney diseases and [read more...]

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Official Blog of the American Journal of Kidney Diseases