pathology – AJKD Blog

Congo Red: From Amyloid to Aspirin

May 29, 2019 // 1 Comment

Congo red is synonymous with amyloidosis. The visually stunning apple green birefringence lights up the eyes and minds of pathologists and nephrologists. Like many histological stains, Congo red was originally a textile dye that was later used to [read more...]

#PathPointer: Congo Red-Positive Always Means Amyloid Deposits, Right?

July 26, 2018 // 1 Comment

Amyloidosis, fibrillary glomerulonephritis (FGN), and immunotactoid glomerulopathy (ITG) are all characterized by renal deposits with an organized substructure under high power electron microscopy. Traditional nomenclature has categorized these [read more...]

PET Scan of the Kidney Reveals An Unusual Finding: Not All That Glitters Is Cancer

May 17, 2018 // 0 Comments

A young man was treated with chemotherapy for diffuse large B cell lymphoma (DLBCL) involving the kidney, liver, and lungs. After 2 cycles, PET imaging showed resolution of tumor foci in the liver and lungs, but a persistent mass in the kidney. [read more...]

Glomerulitis Without Evidence of Antibody-Mediated Rejection

February 23, 2018 // 0 Comments

PathPointers is a new type of blog post that will highlight important everyday teaching points when reviewing kidney histology. These blog posts will be brief and easy-to-read, using real clinical images to demonstrate various biopsy findings. In [read more...]

“Green Smoothie” Oxalate Nephropathy

January 11, 2018 // 1 Comment

A recent AJKD Teaching Case by Makkapati et al describes a 65-year-old patient with Roux-en-Y gastric bypass who developed acute kidney injury (AKI) in the setting of a 10-day “green smoothie cleanse.“ Histology from her kidney biopsy [read more...]

Role of Donor Pre-Implantation Biopsies in Kidney Transplantation

November 22, 2017 // 0 Comments

PathPointers is a new type of blog post that will highlight important everyday teaching points when reviewing kidney histology. These blog posts will be brief and easy-to-read, using real clinical images to demonstrate various biopsy findings. In [read more...]

Light Chain Proximal Tubulopathy – The Tip of the Iceberg?

November 8, 2016 // 1 Comment

In recent years, there has been increased recognition of the spectrum of kidney diseases associated with paraproteinemias. The fact that the pathogenetically related categories of “monoclonal immunoglobulin deposition disease” and “light chain [read more...]

C4 Glomerulopathy: Should We Accept it As a New Disease?

February 29, 2016 // 0 Comments

A recent article published by AJKD reports 3 patients with nephrotic syndrome, two of whom also had hematuria. Kidney biopsy revealed mesangioproliferative glomerulonephritis in one case, membranoproliferative glomerulonephritis in the second [read more...]

Congenital Nephrotic Syndrome: Finnish Type or Diffuse Mesangial Sclerosis?

September 21, 2015 // 0 Comments

Both congenital nephrotic syndrome of Finnish type (CNF) and diffuse mesangial sclerosis (DMS) represent major histopathologic patterns resulting in congenital nephrotic syndrome associated with genetic defects. CNF typically results from germline [read more...]

Recurrent and De Novo FSGS Following Kidney Transplantation

September 14, 2015 // 1 Comment

Atlas Fogo et al Collapsing Glomerulopathy Fig 2

Recurrent FSGS Incidence: 20-40% Risk factors: Childhood onset, rapid progression, recurrence of FSGS in prior transplant Clinical Features: Nephrotic syndrome within weeks after transplantation. Also, can have hematuria, hypertension, and AKI [read more...]